| SUMO化修饰与DNA损伤修复 |
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| 引用本文： | 余婷,郭武华. SUMO化修饰与DNA损伤修复[J]. 生命的化学, 2011, 0(3) |
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| 作者姓名： | 余婷 郭武华 |
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| 作者单位： | 南昌大学第二附属医院肿瘤科; |
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| 基金项目： | 江西省教育厅科技支撑项目(GJJ09107)资助 |
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| 摘 要： | 由于体内外因素的影响,DNA损伤是生物生命周期中的常见现象,如果得不到及时的修复,DNA损伤的积累将导致基因组的不稳定及染色质的异常,并可能导致肿瘤的发生发展。SUMO化修饰是体内一个重要的蛋白质翻译后修饰,越来越多的研究发现SUMO化修饰与多个参与DNA损伤反应、维持基因组稳定的蛋白质相关,有可能参与肿瘤的发生。本文将阐述SUMO化修饰与DNA损伤修复的关系。
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| 关 键 词： | DNA损伤 DNA修复 SUMO修饰 肿瘤 |
Relationship between sumoylation and DNA damage repair |
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| YU Ting,GUO Wuhua. Relationship between sumoylation and DNA damage repair[J]. Chemistry of Life, 2011, 0(3) |
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| Authors: | YU Ting GUO Wuhua |
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| Affiliation: | YU Ting,GUO WuhuaDepartment of Oncology,the Second Affiliated Hospital of Nanchang University,Nanchang 330006,China |
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| Abstract: | DNA damage is present in the whole life cycle of organisms because of the influence of internal and external factors. If it is not timely repaired, the accumulation of the DNA damage will lead to abnormal chromatin and genomic instability, and finally will result in cancers. Sumoylation is an important post-translational modification in cells. More and more studies have suggested that sumoylation affects a large number of proteins that play crucial roles in the DNA damage response or maintaining the stabili... |
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| Keywords: | DNA damage DNA damage repair sumoylation tumor |
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