程序性细胞死亡与肿瘤

程序性细胞死亡（programmed cell death,PCD）是指由基因控制的细胞自主的有序性死亡方式,涉及一系列基因的激活、表达以及调控等。目前,经典细胞凋亡被称为Ⅰ型PCD,而自噬性细胞死亡称为Ⅱ型PCD,坏死样程序性细胞死亡则被称为Ⅲ型PCD,它们在肿瘤的发生、发展及治疗过程中起非常重要的作用。该文结合国内外最新研究进展主要针对不同细胞死亡模式及其相互作用、关键作用蛋白,细胞自噬与肿瘤发生,细胞自噬、凋亡与肿瘤治疗作一简要综述,并展望发展前景,提出在肿瘤治疗中如何利用不同死亡模式的协同作用最大限度地发挥其临床应用价值。

Programmed cell death and cancer

Programmed cell death（PCD） is genetically regulated cell death,involving a series of gene activation,expression and regulation.Currently,the classical apoptosis is considered as type Ⅰ PCD,whereas autophagic cell death is type Ⅱ PCD,necrosis-like programmed cell death is Ⅲ PCD.These modes of cell death play important roles in tumorigenesis,development,and therapeutics.With the most frontier studies in the field,this review mainly discuss cross-talk between apoptosis and autophagy,key interaction proteins,autophagy and tumorigenesis,cell autophagy,apoptosis and cancer therapy.We also further propose some ideas about how to use the favorable factor of autophagy to enhance the efficacy of cancer therapy from the clinical views.