| 研究HCV感染及发病机制的小动物模型 |
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| 引用本文： | 丁存宝,刘海燕,李桂秋,贾长虹,李明,唐红梅.研究HCV感染及发病机制的小动物模型[J].生命科学,2011(5):492-496. |
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| 作者姓名： | 丁存宝 刘海燕 李桂秋 贾长虹 李明 唐红梅 |
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| 作者单位： | 河北联合大学生命科学学院;河北联合大学化工学院;遵化市西郊医院; |
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| 摘 要： | 丙型肝炎病毒（HCV）可导致慢性肝炎,在全球约有1.8亿人感染。当前对于HCV的预防和治疗手段是很有限的,没有有效的疫苗,临床使用干扰素和利巴韦林联用有效率只有55%,而且有明显副作用,因而HCV感染的小动物模型对于抗HCV药物开发以及HCV发病机制的研究是非常重要的;但是HCV只感染人和黑猩猩,存在天然的物种限制。重点介绍利用三种方法克服物种屏障,开发小鼠感染HCV模型的进展,以及转HCV基因小鼠模型前景。
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| 关 键 词： | HCV 小动物模型 异种移植 转基因 |
Small animal model for investigating into HCV infection and pathogenesis |
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| DING Cun-Bao,LIU Hai-Yan,LI Gui-Qiu,JIA Chang-Hong,LI Ming,TANG Hong-Mei.Small animal model for investigating into HCV infection and pathogenesis[J].Chinese Bulletin of Life Sciences,2011(5):492-496. |
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| Authors: | DING Cun-Bao LIU Hai-Yan LI Gui-Qiu JIA Chang-Hong LI Ming TANG Hong-Mei |
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| Institution: | DING Cun-Bao1,LIU Hai-Yan2,LI Gui-Qiu3,JIA Chang-Hong1,LI Ming1,TANG Hong-Mei1(1 Hebei United University,College of Life Science,Tangshan 063009,China,2 Hebei United University,College of Chemical Engineering,3 Zunhua Xijiao Hospital,China) |
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| Abstract: | Hepatitis C virus(HCV) causes chronic liver disease and affects about 180 million people in the world.Treatments for the HCV infection are limited because there is no vaccine and interferon-based treatments are frequently ineffective(SVR 55%) and have significant side effects.A small-animal model for HCV infection is very important to accelerate anti-HCV compound development and HCV pathogenesis.The natural species tropism of HCV is limited to humans and chimpanzees,this paper discusses the prospects of thr... |
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| Keywords: | hepatitis c virus small-animal model xenotransplantation transgenic |
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