| 胶质瘢痕对神经系统损伤的保护作用 |
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| 引用本文： | 盛卸晃,宋淑亮,梁锦锋,吉爱国.胶质瘢痕对神经系统损伤的保护作用[J].生命的化学,2011(2). |
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| 作者姓名： | 盛卸晃 宋淑亮 梁锦锋 吉爱国 |
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| 作者单位： | 山东大学威海分校海洋学院;山大威海国际生物技术研发中心;浙江省药品不良反应监测中心; |
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| 基金项目： | 国家自然科学基金资助项目(30873198)资助 |
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| 摘 要： | 胶质瘢痕是神经系统损伤后由反应性星形胶质细胞,小胶质细胞及其分泌的细胞外基质组成。早期的研究多集中于胶质瘢痕在抑制轴突生长,神经细胞再生等方面的作用。而最新的研究表明胶质瘢痕的形成对损伤急性期神经细胞具有重要的保护作用。本文从瘢痕组织在损伤缝合和组织重构、局部免疫调节、神经再生等方面对神经损伤的保护作用进行综述。
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| 关 键 词： | 胶质瘢痕 神经损伤 反应性星形胶质细胞 |
Protective effect of glial scar on center nervous system injury |
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| SHENG Xiehuang,SONG Shuliang,LIANG Jinfeng,JI Aiguo, Marine School of Sh,ong University at Weihai,Weihai ,China, Sh,ong University-Weihai International Biotechnology Research , Development Center,Zhejiang Center for ADR Monitoring,Hangzhou.Protective effect of glial scar on center nervous system injury[J].Chemistry of Life,2011(2). |
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| Authors: | SHENG Xiehuang SONG Shuliang LIANG Jinfeng JI Aiguo Marine School of Sh ong University at Weihai Weihai China Sh ong University-Weihai International Biotechnology Research Development Center Zhejiang Center for ADR Monitoring Hangzhou |
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| Institution: | SHENG Xiehuang1,2,SONG Shuliang2,LIANG Jinfeng3,JI Aiguo1,21 Marine School of Shandong University at Weihai,Weihai 264029,China,2 Shandong University-Weihai International Biotechnology Research and Development Center,3Zhejiang Center for ADR Monitoring,Hangzhou 310012 |
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| Abstract: | The glial scar consists predominately of reactive astrocytes,microglia and exracellular matrix molecules after center nervous system(CNS) injury.Early studies focused on scar tissue formation inhibiting axonal growth and regeneration.However,increasing evidence indicates that scar tissue and its components might play an important role in the immediate response to CNS injury.Here we reviewed the protective effects of glial scars on sealing the site of injury and remodeling,controlling the local immune respon... |
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| Keywords: | glial scar center nervous system reactive astrocyte |
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