| 局部黏着斑激酶作为肿瘤治疗靶点的研究进展 |
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| 引用本文： | 张文静,黄启来,华子春. 局部黏着斑激酶作为肿瘤治疗靶点的研究进展[J]. 生命科学, 2011, 0(1): 7-12 |
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| 作者姓名： | 张文静 黄启来 华子春 |
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| 作者单位： | 澳门科技大学中医药学院和澳门药物及健康应用研究所;南京大学医药生物技术国家重点实验室; |
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| 基金项目： | 澳门科技发展基金(071/2009/A3,091/2009/A) |
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| 摘 要： | 局部黏着斑激酶（focal adhesion kinase,FAK）是一种非受体型酪氨酸蛋白激酶,是细胞内重要的骨架蛋白与多种信号通路的关键分子。FAK在肿瘤发生、发展、迁移和侵袭的各个阶段都具有重要作用,FAK已经被当作潜在的肿瘤治疗靶点来研究。该综述将对FAK与肿瘤的关系以及FAK作为肿瘤治疗靶点的研究进展进行探讨。
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| 关 键 词： | 局部黏着斑激酶 抗肿瘤 治疗 |
Focal adhesion kinase,a novel target for cancer therapy |
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| ZHANG Wen-Jing,HUANG Qi-Lai,HUA Zi-Chun. Focal adhesion kinase,a novel target for cancer therapy[J]. Chinese Bulletin of Life Sciences, 2011, 0(1): 7-12 |
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| Authors: | ZHANG Wen-Jing HUANG Qi-Lai HUA Zi-Chun |
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| Affiliation: | ZHANG Wen-Jing1,HUANG Qi-Lai1*,HUA Zi-Chun1,2*(1Faculty of Chinese Medicine and Macau Institute for Applied Research in Medicine and Health,Macau University of Science and Technology,Macau,China,2The State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,China) |
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| Abstract: | Focal adhesion kinase(FAK),a cytoplasmic non-receptor protein tyrosine kinase,serves as both a molecular scaffold and a mediator participating in multiple signal transduction pathways.FAK is involved in tumor cell survival,proliferation,migration and metastasis.Currently,FAK has been regarded as a potential target for cancer therapy.This review is to summarize the relationship between FAK and tumor progression,and to discuss the strategies targeting FAK for cancer treatment. |
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| Keywords: | focal adhesion kinase antitumor treatment |
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