| STIM和Orai在钙库操纵的钙内流途径及心脑血管疾病中的作用 |
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| 引用本文： | 梁霄,何芳.STIM和Orai在钙库操纵的钙内流途径及心脑血管疾病中的作用[J].生命的化学,2011(3). |
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| 作者姓名： | 梁霄 何芳 |
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| 作者单位： | 新疆石河子大学医学院病理生理学教研室新疆地方与民族高发病教育部重点实验室; |
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| 基金项目： | 国家自然科学基金资助项目(30860099)资助 |
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| 摘 要： | 钙库操纵的钙内流(SOCE)是调节钙离子(Ca2+)内流进入细胞最普遍的一种途径,它的通道称为钙库操纵的钙内流通道(SOC)。SOC存在于大多数非兴奋细胞和部分兴奋细胞上,近年来确定,STIM和Orai是组成SOC的两种主要蛋白质。本文就近年来对SOCE途径的机制,STIM和Orai不同亚型的结构、功能及在心脑血管疾病中的作用作一综述。
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| 关 键 词： | 钙库操纵的钙内流 钙库操纵的钙离子通道 STIM Orai |
The roles of STIM and Orai proteins in the store-operated Ca~(2+) entry pathway and cardiovascular and cerebrovascular diseases |
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| LIANG Xiao,HE Fang.The roles of STIM and Orai proteins in the store-operated Ca~(2+) entry pathway and cardiovascular and cerebrovascular diseases[J].Chemistry of Life,2011(3). |
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| Authors: | LIANG Xiao HE Fang |
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| Institution: | LIANG Xiao,HE Fang Department of Pathophysiology,Medical College of Shihezi University,Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi 832002,China |
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| Abstract: | The most ubiquitous pathway for regulated calcium (Ca2+) entry into the cells is the store-operated Ca2+ entry (SOCE) pathway. This channel is called store operated Ca2+ channel (SOC). SOC exists in the most non-excitable cells and some excitable cells. Recently, two major players for SOC have been discovered: STIM and Orai. This paper reviews the signaling mechanism of SOCE, the structure and function of different subgroups of STIM and Orai proteins, as well as their roles in cardiovascular and cerebrovasc... |
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| Keywords: | store-operated Ca2 entry store-operated Ca2 channel STIM Orai |
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