The influence of spatial pulsed magnetic field application on neuropathic pain after tibial nerve transection in rat |
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Authors: | Sebastian Szajkowski Adam Właszczuk Grzegorz Cieślar Marita Pietrucha-Dutczak Aleksander Sieroń |
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Affiliation: | 1. Department of Physiology, Medical University of Silesia, KatowicePoland;2. Clinical Department of Internal Diseases, Angiology and Physical Medicine;3. Centre of Diagnostics and Laser Therapy in Bytom, Medical University of SilesiaKatowicePoland |
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Abstract: | The purpose of the study was to examine the influence of the spatial variable magnetic field (induction: 150–300?µT, 80–150?µT, 20–80?µT; frequency 40?Hz) on neuropathic pain after tibial nerve transection. The experiments were carried out on 64 male Wistar C rats. The exposure of animals to magnetic field was performed 1?d/20?min., 5?d/week, for 28?d. Behavioural tests assessing the intensity of allodynia and sensitivity to mechanical and thermal stimuli were conducted 1?d prior to surgery and 3, 7, 14, 21 and 28?d after the surgery. The extent of autotomy was examined. Histological and immunohistochemical analysis was performed. The use of extremely low-frequency magnetic fields of minimal induction values (20–80?µT/40?Hz) decreased pain in rats after nerve transection. The nociceptive sensitivity of healthy rats was not changed following the exposition to the spatial magnetic field of the low frequency. The results of histological and immunohistochemical investigations confirm those findings. Our results indicate that extremely low-frequency magnetic field may be useful in the neuropathic pain therapy. |
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Keywords: | Allodynia hyperalgesia magnetic field neuropathic pain peripheral nervous system |
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