A simple formula useful for positional cloning. |
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| Authors: | Richard T Durrett Kai-Yi Chen Steven D Tanksley |
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| Affiliation: | Department of Mathematics, Cornell University, Ithaca, New York 14853-4201, USA. |
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| Abstract: | We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis. |
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