Corticotropin-releasing factor (CRF): mechanism to elevate mean arterial pressure and heart rate |
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| Authors: | L A Fisher G Jessen M R Brown |
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| Affiliation: | Peptide Biology Laboratory, The Salk Institute, P.O. Box 85800, San Diego, CA 92138, U.S.A. |
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| Abstract: | The efferent mechanisms by which central administration of corticotropin-releasing factor (CRF) elevates mean arterial pressure and heart rate were assessed in unanesthetized, unrestrained rats. CRF increased blood pressure and heart rate by stimulating noradrenergic sympathetic nervous outflow. CRF-induced cardiovascular changes were not dependent on anterior pituitary hormone release, adrenomedullary epinephrine secretion, the renin-angiotensin system or circulating vasopressin. |
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| Keywords: | corticotropin-releasing factor sympathetic nervous system cardiovascular regulation |
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