Multiple facets of TRPML1 in autophagy |
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| Affiliation: | 1. Collaborative Innovation Center for Biomedicine, School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, China;2. Departments of Physiology and Biophysics, Dalhousie University, 5850 College Street, Halifax, B3H 4R2, Nova Scotia, Canada;1. Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, USA;2. Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA;3. Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA;4. Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore 169857, Singapore;5. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA;1. Center for Dementia Research, Nathan S. Kline Institute, Orangeburg, NY 10962, USA;2. Department of Psychiatry, New York University, New York, NY 10016, USA;3. Department of Pathology, New York University, New York, NY 10016, USA;4. Department of Cell Biology, New York University, New York, NY 10016, USA;5. Division of Pathophysiology and Repair, Cardiff University, Cardiff CF10 3XQ, UK;6. Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, PA 19104, USA;7. Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA;8. Pharmaceutical Science and Ophthalmology, University of Colorado, Aurora, CO 80045, USA;3. Departments of Physiology and Biophysics;5. Biochemistry and Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia B3H 4R2, Canada;4. Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Cytology and Genetics, Northeast Normal University, Changchun, 130024 Jilin, China;6. Department of Chemistry, Dalhousie University, 6274 Coburg Road, Halifax, Nova Scotia B3H 4R2, Canada;1. The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China;2. Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA;3. Graduate Program in Cell and Regulatory Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA;4. Center for Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030, USA;1. Department of Physiology and Biophysics, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, B3H 4R2, Nova Scotia, Canada;2. Key Laboratory of Molecular Epigenetics, Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, Changchun, 130021, China;3. Department of Physiology, School of Basic Medicine, Anhui Medical University, Hefei,230032, China;4. Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China |
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| Abstract: | 
Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases. |
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| Keywords: | TRPML1 Lysosome Autophagy mTORC1 |
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