| 硫化氢与NADPH氧化酶 |
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| 引用本文： | 逯爱梅,于天贵,司毅.硫化氢与NADPH氧化酶[J].生命的化学,2010(2). |
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| 作者姓名： | 逯爱梅 于天贵 司毅 |
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| 作者单位： | 济南市传染病医院;山东医学高等专科学校; |
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| 摘 要： | 硫化氢(H2S)被认为是继NO和CO之后的第三种气体信号分子,是一种新的内皮细胞源性血管舒张因子,在平滑肌松弛、海马长时程增强、脑发育和炎症等方面发挥着重要的生理病理作用。H2S具有很强的抗氧化作用,被认为是其发挥生理病理作用的重要机制之一。NADPH氧化酶是生物体内产生活性氧类(reactive oxygen species,ROS)的主要酶,在动脉粥样硬化、肾间质纤维化等的发生和发展起着关键作用。本文重点综述生理浓度下H2S对NADPH氧化酶的抑制作用及其机制,并简述其重要的生理病理意义。
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| 关 键 词： | 硫化氢 NADPH氧化酶 抗氧化 |
Hydrogen sulfide and NADPH oxidase |
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| Ai-Mei Lu,Tian-Gui Yu,Yi Si Jinan Infectious Disease Hospital,Jinan ,China,Sh,ong Medical College,Jinan.Hydrogen sulfide and NADPH oxidase[J].Chemistry of Life,2010(2). |
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| Authors: | Ai-Mei Lu Tian-Gui Yu Yi Si Jinan Infectious Disease Hospital Jinan China Sh ong Medical College Jinan |
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| Institution: | Ai-Mei Lu1,Tian-Gui Yu2,Yi Si2 1Jinan Infectious Disease Hospital,Jinan 250021,China,2Sh,ong Medical College,Jinan 250002 |
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| Abstract: | Hydrogen sulfide (H2S) has been found to be the third endogenous gas signal molecule after NO and CO in animals.It has been implicated in the induction of smooth muscle relaxation,hippocampal long term potentiation,brain development,inflammation and so on.Recently,a number of researches have shown that H2S exerts its effects in biological systems through its antioxidant activities.NADPH oxidase is a multi-protein complex producing reactive oxygen species (ROS) both in phagocytic cells and non-phagocytic cel... |
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| Keywords: | hydrogen sulfide NADPH oxidase antioxidation |
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