Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries |
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| Authors: | H Rakugi Y Tabuchi M Nakamaru M Nagano K Higashimori H Mikami T Ogihara |
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| Institution: | Department of Geriatric Medicine, Osaka University Medical School, Japan. |
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| Abstract: | The effects of endothelin on the vascular renin-angiotensin system were examined in isolated perfused rat mesenteric arteries by measuring vascular renin activity and angiotensin II released into the perfusate. Infusion of endothelin (10(-9)M and 10(-11)M) increased the vascular renin activity and angiotensin II release. Pretreatment with nicardipine (10(-6)M), a calcium channel blocker, significantly suppressed these effects of endothelin. These results suggest that endothelin activates the vascular renin-angiotensin system via intracellular calcium metabolism. Vascular angiotensin II produced by endothelin may modulate the local effect of endothelin on the resistance vessels. |
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