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Influence of Exon Duplication on Intron and Exon Phase Distribution |
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| Authors: | Alexey Fedorov Larisa Fedorova Valery Starshenko Vadim Filatov Eugeni Grigor'ev |
| Institution: | (1) Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics, Academy of Sciences of Russia, Moscow 123182, Russia, RU;(2) Sussex Centre for Neuroscience, IRC, Sussex University, Falmer, Brighton BN1 9QG, U.K., GB;(3) Laboratory of Isotopic Research, V.A. Engelhardt Institute of Molecular Biology, Academy of Sciences of Russia, Moscow 117984, Russia, RU;(4) Laboratory of non-linear optical frequency conversion, Industrial Institute, Zaporozhye 330006, Ukraine, UA;(5) Department of Biopolymer Function and Structure Research, Institute of Molecular Genetics, Academy of Sciences of Russia, Moscow 123182, Russia, RU |
| Abstract: | Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness. All of the nonrandomness is probably due to both the processes of exon duplication and shuffling. A quantitative estimation of exon duplications in the human genome and their influence on the intron and exon phase distributions has been analyzed. According to our estimation, the proportion of duplicated exons in the human genome constitutes at least 6% of the total. Generalizing the particular case of exon duplication to the more common event of exon shuffling, we modeled and analyzed the influence of exon shuffling on intron phase distribution. Received: 28 March 1997 / Accepted: 9 July 1997 |
| Keywords: | : Human genes — Exon/intron gene structure — Intron phase order — Exon shuffling — Gene evolution |
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