Fucoxanthin-rich seaweed extract suppresses body weight gain and improves lipid metabolism in high-fat-fed C57BL/6J mice |
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Authors: | Seon-Min Jeon Hye-Jin Kim Myoung-Nam Woo Mi-Kyung Lee Young Chul Shin Yong Bok Park Dr Myung-Sook Choi |
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Institution: | 1. Department of Food Science and Nutrition, Kyungpook National University, Daegu, Republic of Korea;2. Foods R&D, CJ CheilJedang Corp., Seoul, Republic of Korea;3. Department of Food and Nutrition, Sunchon National University, Suncheon, Republic of Korea;4. Amicogen, Inc., Jinsung, Jinju, Republic of Korea;5. School of Life Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea |
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Abstract: | An ethanol extract of fucoxanthin-rich seaweed was examined for its effectiveness as a nutraceutical for body fat-lowering agent and for an antiobese effect based on mode of actions in C57BL/6J mice. Animals were randomized to receive a semi-purified high-fat diet (20% dietary fat, 10% corn oil and 10% lard) supplemented with 0.2% conjugated linoleic acid (CLA) as the positive control, 1.43% or 5.72% fucoxanthin-rich seaweed ethanol extract (Fx-SEE), equivalent to 0.05% or 0.2% dietary fucoxanthin for six weeks. Results showed that supplementation with both doses of Fx-SEE significantly reduced body and abdominal white adipose tissue (WAT) weights, plasma and hepatic triglyceride (TG), and/or cholesterol concentrations compared to the high-fat control group. Activities of adipocytic fatty acid (FA) synthesis, hepatic FA and TG synthesis, and cholesterol–regulating enzyme were also lowered by Fx-SEE supplement. Concentrations of plasma high-density lipoprotein-cholesterol, fecal TG and cholesterol, as well as FA oxidation enzyme activity and UCP1 mRNA expression in epididymal WAT were significantly higher in the Fx-SEE groups than in the high-fat control group. CLA treatment reduced the body weight gain and plasma TG concentration. Overall, these results indicate that Fx-SEE affects the plasma and hepatic lipid profile, fecal lipids and body fat mass, and alters hepatic cholesterol metabolism, FA synthesis and lipid absorption. |
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Keywords: | Antiobesity Cholesterol synthesis Fatty acid synthesis Fucoxanthin rich seaweed ethanol extract Lipid absorption |
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