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Synthesis and antitumor activity of camptothecin derivatives bearing five-membered heterocycle containing 10-substituents |
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| Authors: | Rulin Zhao Bernadette Oreski J William Lown |
| Institution: | a Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2G2 b SynPhar Laboratories Inc, 4290-91a Street, Edmonton, Alberta, Canada, T6E 5V2 |
| Abstract: | A series of new camptothecin derivatives bearing five-membered ring heterocycle containing substituents in the 10-position were synthesized and evaluated for in vitro cytotoxic activity. Camptothecin derivatives bearing a pyrrole or a thiophene ring were significantly more potent than camptothecin, however those bearing furan were less potent than camptothecin. |
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