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Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells
Affiliation:1. Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA;2. Division of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA;3. Division of Genetics, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA;4. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA;5. Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA;6. Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA;7. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA;8. Cancer Metabolism DPU, GlaxoSmithKline, Collegeville, PA 19426, USA;9. Center for Regulatory and Environmental Analytical Metabolomics;10. Department of Surgery, University of Louisville, Louisville, KY 40208, USA
Abstract:
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