Zinc prevention of electromagnetically induced damage to rat testicle and kidney tissues |
| |
Authors: | Ahmet Ozturk Abdülkerim Kasim Baltaci Rasim Mogulkoc Esma Öztekin |
| |
Institution: | (1) Department of Urology, Selcuk University, Konya, Turkey;(2) Department of Physiology, Selcuk University, Konya, Turkey;(3) Department of Biochemistry, Meram Medical Faculty, Selcuk University, Konya, Turkey |
| |
Abstract: | The aim of this study was to investigate the extent of lipid peroxidation when zinc is administered to rats periodically exposed
to a 50-Hz electromagnetic field for 5 min at a time over a period of 6 mo. Twenty-four Sprague-Dawley adult male rats were
subdivided in groups of eight animals each. Group 1 served as untreated controls, group 2 was exposed to an electromagnetic
field but received no additional treatment, and group 3 was exposed to electromagnetic radiation and treated with 3-mg/kg
daily intraperitoneal injections of zinc sulfate. The erythrocyte glutathione activity (GSH) and the plasma, testicle, and
kidney tissue levels of zinc (Zn) and of malondialdehyde (MDA) were measured in all of the animals.
The plasma and testicle MDA levels in group 2 were higher than those in groups 1 and 3, with group 3 values significantly
higher than those in group 1 (p<0.001). The kidney MDA levels in group 2 were higher than in groups 1 and 3 (p<0.001). The erythrocyte GSH level was lower in group 2 than in groups 1 and 3, with group 1 significantly lower than group
3 (p<0.001). In testicle and kidney tissues, the GSH levels in group 1 were lower than for groups 2 and 3, with group 2 significantly
lower than group 3 (p<0.001) The plasma zinc levels were highest in group 3, followed by group 1 and group 2, which showed the lowest value (p<0.001).
These results indicate that testicle and kidney tissue damage caused by periodic exposure to an electromagnetic field are
ameliorated or prevented by zinc supplementation. |
| |
Keywords: | Electromagnetic field free radicals oxidative damage zinc |
本文献已被 PubMed SpringerLink 等数据库收录! |
|