Influenza A hemagglutinin C-terminal anchoring peptide: identification and mass spectrometric study |
| |
| Authors: | Kordyukova Larisa V Ksenofontov Aleksander L Serebryakova Marina V Ovchinnikova Tatyana V Fedorova Natalija V Ivanova Valeria T Baratova Ludmila A |
| |
| Affiliation: | A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119992, Russia. kord@belozersky.msu.ru |
| |
| Abstract: | MALDI-TOF MS and N-terminal amino acid sequencing allowed us to identify several fragments of the C-terminal peptide of Influenza A hemagglutinin (HA) containing transmembrane domains (TMD). These fragments were detected in the organic phase of chloroform-methanol extracts from bromelain-treated virus particles. Heterogeneous fatty acylation of the C-terminus was revealed. Tritium bombardment technique might open an opportunity for 3D structural investigation of the HA TMD in situ. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
