Cardiac Effects of Magnesium Sulfate Pretreatment on Acute Dichlorvos-Induced Organophosphate Poisoning: An Experimental Study in Rats |
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Authors: | Nurullah Gunay Zeynep Kekec Seniz Demiryurek Ataman Kose Emine S Namiduru Nahide E Gunay Ibrahim Sari Abdullah T Demiryurek |
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Institution: | (1) Department of Emergency Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey;(2) Department of Emergency Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey;(3) Gaziantep School of Health, and Department of Physiology, Faculty of Medicine, Gaziantep, Turkey;(4) Department of Emergency Medicine, Twenty-Five December State Hospital, Gaziantep, Turkey;(5) Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey;(6) Department of Biochemistry and Clinical Biochemistry, Gaziantep Pediatric Hospital, Gaziantep, Turkey;(7) Department of Pathology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey;(8) Department of Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey |
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Abstract: | Although atropine and oximes are traditionally used in the management of organophosphate poisoning, investigations have been
directed to finding additional therapeutic approaches. Thus, the aim of this study was to evaluate the cardiac effects of
magnesium sulfate pretreatment on dichlorvos intoxication in rats. Rats were randomly divided into three groups as control,
dichlorvos, and magnesium sulfate groups. After 6 h of dichlorvos or corn oil (as a vehicle) injection, venous blood samples
were collected, and cardiac tissue samples were obtained. Biochemical analyses were performed to measure some parameters on
serum and cardiac tissue. Immunohistochemical analyses of apoptosis and inducible nitric oxide (NO) synthase showed no change
in cardiac tissue. Serum cholinesterase levels were markedly depressed with dichlorvos, and further suppressed markedly with
magnesium sulfate pretreatment. Although we have demonstrated that serum NO levels in dichlorvos and magnesium sulfate groups
were lower than the control group, cardiac tissue NO levels in magnesium sulfate group were higher than the other two groups.
Mortality was not significantly affected with magnesium sulfate pretreatment. Uncertainty still persists on the right strategies
for the treatment of organophosphate acute poisoning; however, it was concluded that our results do not suggest that magnesium
sulfate therapy is beneficial in the management of acute dichlorvos-induced organophosphate poisoning, and also further studies
are required. |
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