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Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR |
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| Authors: | Wu Zhicai Fraley Mark E Bilodeau Mark T Kaufman Mildred L Tasber Edward S Balitza Adrienne E Hartman George D Coll Kathleen E Rickert Keith Shipman Jennifer Shi Bin Sepp-Lorenzino Laura Thomas Kenneth A |
| Affiliation: | Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA. zhicai_wu@merck.com |
| Abstract: | 3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility. |
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