病毒性肝炎患者抗—HBcIgA 、IgE 、IgG 、IgM 平行检测的临床意义

目的：通过对乙肝病人血清抗-HBcIgA、HBcIgE、HbcIgc、HbcIgM平行检测进一步地探讨其临床应用价值。方法：收集216份乙肝病人血清（均为我院住院病人的血清），采用ELISA法对病人血清抗-HBcIgA、HBcIgE、HBcIgc、HBcIgM平行检测，并对检测结果作统计学分析。结果：检测结果表明：抗-HBcIgA是HBV感染后肝脏损害的明显标志，抗-HBdgE是HBV感染后乙型肝炎慢性化的标志，抗-HBcIgG持续存在则是以往感染的标志，抗-HBcIgM是HBV感染后病毒持续复制的标志。结论：在急慢性乙型肝炎、慢活肝与慢迁肝鉴别诊断中，平行检测病人血清抗-HBcIgA、HBcIgE、HbcIgG、HbcIgM对乙型肝炎慢性化及其预后估价均有重要临床意义。

Parallel Examination of Anti -HBcIgA, IgE, IgG, and IgM of Patients with Virus Hepatitis

Objective: To further study the clinical application value of parallel examination of anti-HBcIgA, HBcIgE, HBcIgG and HBcIgM in the sera of patients with hepatitis B(HB). Methods: 216 blood specimens of HB patients,who were in-patients in our hospital,were collected and examined.And the levels of anti-HBcIgA, HBcIgE,HBcIgG and HBcIgM in the sera of the patients were statistically analysed. Results: The results showed that anti-HBcIgA was the identification marker of liver lesion post infection of HBV, anti-HBcIgE wa the chronicity marker of HB post infection of HBV, anti-HBcIgG persistence existence was the infection marker in the past, and anti-HBcIgM was the marker of virus persistence replication post infection of HBV. Conclusion: In the differential diagnosis of acute or chronic HB, chronic active hepatitis and chronic persistent hepatitis, parallel examining anti-HBcIgA, HBcIgE, HBcIgG and HBcIgM in the sera of the patients will be a significant means for HB chronicity and prognosis.