被膜蛋白糖基化在HIV感染中的作用

在HIV感染过程中,病毒被膜蛋白糖基化起着重要作用。它使病毒粒子具有高度糖基化的表面,帮助HIV逃避人体免疫细胞识别和攻击。在病毒入侵时,被膜糖蛋白与宿主细胞表面的受体结合,并进行一系列构象变化,使病毒粒子顺利地与宿主细胞膜融合。介绍近年来对被膜蛋白糖基化过程与HIV成熟、感染和逃避免疫应答等方面分子水平作用机理的深入了解,这些作用机理将会有助于艾滋病疫苗的研制和以“糖链为靶”药物的开发。

Functions of Envelope Proteins Glycosylation in HIV Infection

The envelope glycoproteins play an important role in the infection of human immunodeficiency viruses HIV.By the host machinery,the glycosylation of these proteins protect potential protein antigenic epitopes on the virus.During the entry of HIV into cells,the envelope glycoproteins bind receptors on target cell membrane and mediate the virus entry by fusing the viral and cell membranes.We summarize current understanding of the molecular mechanisms of immune response escape,infection,maturation of HIV and glycosylation of envelope proteins.These mechanisms should guide a possible antiviral strategy to inhibit glycosylation and aid in HIV vaccine development. ;