The role of the MAPK pathway alterations in GM-CSF modulated human neutrophil apoptosis with aging |
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| Authors: | Anis?Larbi,Nadine?Douziech,Carl?Fortin,Annie?Linteau,Gilles?Dupuis,Tamas?FulopJr mailto:tamas.fulop@usherbrooke.ca" title=" tamas.fulop@usherbrooke.ca" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | (1) Laboratory of Immunology, Research Center on Aging, University of Sherbrooke, Qc, Canada;(2) Immunology Graduate Program, Clinical Research Center, Faculty of Medicine, University of Sherbrooke, Qc, Canada;(3) Signal Transduction Laboratory, Department of Biochemistry, University of Sherbrooke, Qc, Canada;(4) Department of Medicine, Geriatrics Division, Faculty of medicine, University of Sherbrooke, Qc, Canada |
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| Abstract: | ![]()
Background Neutrophils represent the first line of defence against aggressions. The programmed death of neutrophils is delayed by pro-inflammatory stimuli to ensure a proper resolution of the inflammation in time and place. The pro-inflammatory stimuli include granulocyte-macrophage colony-stimulating factor (GM-CSF). Recently, we have demonstrated that although neutrophils have an identical spontaneous apoptosis in elderly subjects compared to that in young subjects, the GM-CSF-induced delayed apoptosis is markedly diminished. The present study investigates whether an alteration of the GM-CSF stimulation of MAPKs play a role in the diminished rescue from apoptosis of PMN of elderly subjects. |
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