首页 | 本学科首页   官方微博 | 高级检索  
     


Dissecting the fungal biology of Bipolaris papendorfii: from phylogenetic to comparative genomic analysis
Authors:Chee Sian Kuan  Su Mei Yew  Yue Fen Toh  Chai Ling Chan  Yun Fong Ngeow  Kok Wei Lee  Shiang Ling Na  Wai-Yan Yee  Chee-Choong Hoh  Kee Peng Ng
Affiliation:1.Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia;2.Codon Genomics SB, Jalan Bandar Lapan Belas, Selangor Darul Ehsan 47160, Malaysia
Abstract:Bipolaris papendorfii has been reported as a fungal plant pathogen that rarely causes opportunistic infection in humans. Secondary metabolites isolated from this fungus possess medicinal and anticancer properties. However, its genetic fundamental and basic biology are largely unknown. In this study, we report the first draft genome sequence of B. papendorfii UM 226 isolated from the skin scraping of a patient. The assembled 33.4 Mb genome encodes 11,015 putative coding DNA sequences, of which, 2.49% are predicted transposable elements. Multilocus phylogenetic and phylogenomic analyses showed B. papendorfii UM 226 clustering with Curvularia species, apart from other plant pathogenic Bipolaris species. Its genomic features suggest that it is a heterothallic fungus with a putative unique gene encoding the LysM-containing protein which might be involved in fungal virulence on host plants, as well as a wide array of enzymes involved in carbohydrate metabolism, degradation of polysaccharides and lignin in the plant cell wall, secondary metabolite biosynthesis (including dimethylallyl tryptophan synthase, non-ribosomal peptide synthetase, polyketide synthase), the terpenoid pathway and the caffeine metabolism. This first genomic characterization of B. papendorfii provides the basis for further studies on its biology, pathogenicity and medicinal potential.
Keywords:dematiaceous   Bipolaris papendorfii   Cochliobolus   Curvularia   LysM domain
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号