Association of Helicobacter pylori and gastric autoimmunity: A population-based study |
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| Authors: | Raivo Uibo,Tamara Vorobjova,Kaja Metskü la,Kalle Kisand,Torkel Wadströ m,Tiiu Kivik |
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| Affiliation: | Institute of General and Molecular Pathology, University of Tartu, 34 Veski Street, Tartu EE2400, Estonia;Department of Medical Microbiology, University of Lund, Lund S-22362, Sweden;Karksi-Nuia Out-Patients Department, Viljandi County, Karksi-Nuia EE3644, Estonia |
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| Abstract: | ![]()
Abstract Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed. |
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| Keywords: | Helicobacter pylori IgG antibody Parietal cell antibody Gastric autoimmunity Chronic gastritis Amino acid sequence |
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