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Elevated Hsp90-beta contributes to differential diagnosis of pleural effusion caused by lung cancer and correlates with malignant biological behavior of lung cancer
Authors:Rong Biaoxue  Li Min  Fu Tian  Gao Wenlong  Liu Hua
Affiliation:1.Department of Respiratory Medicine, First Affiliated Hospital,Xi’an Medical University,Xi’an,China;2.Department of Respiratory Medicine,Shenmu Hospital,Shenmu,China;3.Department of respiratory Medicine,Jining NO.1 People’s Hospital,Jining,China;4.Institute of Epidemiology and Health Statistics, School of Public Health,Lanzhou University,Lanzhou,China;5.Department of Respiratory Medicine,Gansu Provincial Hospital,Lanzhou,China
Abstract:

Background

Hsp90-beta has been investigated to be correlated with the occurrence and development of tumor. The intention of this research was to test the level of Hsp90-beta in malignant pleural effusion (MPE) of patients with lung cancer and disclose the clinical significance of Hsp90-beta as a potential tumor marker for differential diagnosis of pleural effusion caused by lung cancer.

Methods

The level of Hsp90-beta was determined using enzyme-linked immunosorbent assay. Calculations of the Hsp90-beta threshold, the sensitivity and specificity for distinguishing MPE from benign pleural effusion were performed using receiver operator characteristic curve.

Results

The level of Hsp90-beta in MPE of lung cancer patients was higher than that in control individuals (P P 

Conclusions

Increased Hsp90-beta in MPE was correlated with malignant biological behavior of lung cancer patients, indicating that the level of Hsp90-beta could be a tool of referential value for differential diagnosis of pleural effusion caused by lung cancer.
Keywords:
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