Measurement of protein activator levels in experimental diabetic rat adipose tissue. |
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Authors: | S S Solomon M Silberberg M Palazzolo |
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Institution: | 1. Research Service Veterans Administration Hospital, Memphis, TN 38104 USA;2. Department of Medicine Veterans Administration Hospital, Memphis, TN 38104 USA;3. University of Tennessee Center for the Health Sciences, Memphis, TN 38104 USA |
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Abstract: | Experimental diabetes induced by streptozotocin has been shown to decrease the level of cyclic AMP phosphodiesterase activity in rat adipose tissue. This reduced activity was restored with insulin. Protein activator, a small molecular weight substance, is essential for full activity of some component phosphodiesterases. Herein we demonstrate a significant decrease in protein activator level in the 13,000 X g boiled supernatant from streptozotocin-diabetic rat adipose tissue. However, although a decrease in protein activator level is consistent with diabetic inactivation of phosphodiesterase activity, additional studies presented here suggest that a defect in the diabetic phosphodiesterase enzyme itself also contributed to the decrease of total phosphodiesterase activity. |
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