Calculation of tumour and normal tissue biological effective dose in 90Y liver radioembolization with different dosimetric methods |
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| Institution: | 1. S.C. Fisica Sanitaria, A.O.U. Città della Salute e della Scienza, Corso Bramante 88/90, 10126 Turin, Italy;2. S.C. Fisica Sanitaria, A.O. Ordine Mauriziano, via Ferdinando Magellano 1, 10128 Turin, Italy;3. S.C. Medicina Nucleare U, A.O.U. Città della Salute e della Scienza, Corso Bramante 88/90, 10126 Turin, Italy;4. S.C. Medicina Nucleare, A.O. Ordine Mauriziano, via Ferdinando Magellano 1, 10128 Turin, Italy;1. Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920;2. Molecular Imaging and Translational Research Program, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920;3. Department of Radiology, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920;1. Department of Radiology and Imaging Sciences, Indiana University, 550 N. University Boulevard, Room 0663, Indianapolis, IN 46202;2. School of Health Sciences, Purdue University, West Lafayette, Indiana;1. Department of Radiology, Indiana University School of Medicine, 550 N. University Boulevard, Room 0663, Indianapolis, IN 46202;2. Biocompatibles UK Ltd, a BTG International group company, Camberley, Surrey, United Kingdom;1. Department of Radiology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215;2. Massachusetts General Hospital, 55 Fruit Street GRB 298, Boston, MA 02114;3. Boston Medical Center, One Boston Medical Center Place, Boston, MA 02118;1. Nuclear Medicine Department, Hôpital Européen Georges Pompidou (HEGP), Paris, France;2. Nuclear Medicine Department, Centre Hospitalier Princesse Grace, Monaco;3. Laboratoire d''Evaluation de la Dose Interne (LEDI), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-Aux-Roses, France;1. St. Vincent’s University Hospital, Ireland;2. University College Dublin, Ireland |
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| Abstract: | PurposeRadioembolization with 90Y microspheres is an effective treatment for unresectable liver tumours. Two types of microspheres are available: resin (SIR-Spheres®) and glass (Theraspheres®). The aim of this study is to compare biological effective dose (BED) values obtained with three different dosimetric methods.Methods29 HCC patients were included in this study: 15 were treated with resin(mean injected activity 1.5 GBq, range 0.8–2.7 GBq) and 14 with glass microspheres (2.6 GBq, range 1.3–4.1 GBq). Average doses to tumours and normal liver tissues were calculated with AAPM, multi-compartmental MIRD and Voxel-based methods and consequently the BED values were obtained. Planar images were used for the AAPM method: 99mTc-MAA SPECT-CT attenuation and scatter corrected images (resin) and 99m Tc-MAA SPECT attenuation corrected (glass) were employed for the other two methods.ResultsRegardless of type of microspheres, both for tumours and normal liver tissues, no significant statistical differences were found between MIRD and Voxel for both doses and BED values. Conversely AAPM gave discordant results with respect to the other two methods (Mann-Whitney p-values ⩽ 0.01). For resin spheres the calculated tumour-to-normal tissue ratios on planar images were on average 14 times greater than those obtained on SPECT-CT images, while they were 4 times greater on glass. A linear correlation was observed between MIRD and Voxel BEDs.ConclusionsThe AAPM method appears to be less precise for absorbed dose and BED estimation, while MIRD and voxel based dosimetry are more confident each other. |
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| Keywords: | Yttrium-90 BED Dosimetry Microspheres |
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