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3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk
Institution:1. Division of Human Genetics and Endocrinology & Diabetes, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA;2. Center for Spatial and Functional Genomics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA;3. Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;4. Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;5. Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;6. The Human Pancreas Analysis Program (RRID: SCR_016202);7. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;8. Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;9. Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
Abstract:
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  • Keywords:type 2 diabetes  3D chromatin maps  islets of Langerhans  alpha cell  beta cell  acinar cell
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