Extra-embryonic endoderm cells derived from ES cells induced by GATA Factors acquire the character of XEN cells |
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| Authors: | Daisuke Shimosato Makoto Shiki Hitoshi Niwa |
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| Institution: | (1) Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe Hyogo, 650-0047, Japan;(2) Laboratory for Development and Regenerative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunokicho, Chuo-ku, 650-0017 Kobe, Hyogo, Japan;(3) CREST (Core Research for Evolutional Science and Technology), Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan |
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| Abstract: | Background Three types of cell lines have been established from mouse blastocysts: embryonic stem (ES) cells, trophoblast stem (TS) cells,
and extra-embryonic endoderm (XEN) cells, which have the potential to differentiate into their respective cognate lineages.
ES cells can differentiate in vitro not only into somatic cell lineages but into extra-embryonic lineages, including trophectoderm and extra-embryonic endoderm
(ExEn) as well. TS cells can be established from ES cells by the artificial repression of Oct3/4 or the upregulation of Cdx2 in the presence of FGF4 on feeder cells. The relationship between these embryo-derived XEN cells and ES cell-derived ExEn
cell lines remains unclear, although we have previously reported that overexpression of Gata4 or Gata6 induces differentiation of mouse ES cells into extra-embryonic endoderm in vitro. |
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