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Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging
Authors:Sebastian Lugert  Onur Basak  Philip Knuckles  Ute Haussler  Klaus Fabel  Magdalena Götz  Carola A. Haas  Gerd Kempermann  Verdon Taylor  Claudio Giachino
Affiliation:1. Department of Molecular Embryology, Max Planck Institute of Immunobiology, Stubeweg 51, D-79108 Freiburg, Germany;2. Neurocenter, University of Freiburg, Breisacher Strasse 64, D-79106 Freiburg, Germany;3. Genomics of Regeneration, Center for Regenerative Therapies Dresden, Tatzberg 47-49, D-01307 Dresden, Germany;4. Institute for Stem Cell Research, Helmholtz Zentrum Munchen, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Munich, Germany;5. Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Schillerstrasse 46, D-80336 Munich, Germany;6. Centre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN Sheffield, UK
Abstract:
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  • Highlights? Notch signaling defines morphologically distinct hippocampal stem cell populations ? Radial and horizontal hippocampal stem cells depend on canonical Notch signaling ? Different neural stem cell subpopulations respond selectively to neurogenic stimuli ? Aging results in a reversible transition of stem cells to a quiescent state
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