Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, <sup>1</sup>H NMR and molecular dynamics simulation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Conformational studies of a benzodiazepine-like peptide in SDS micelles by circular dichroism, ¹H NMR and molecular dynamics simulation

Authors:	Marc Lecouvey Céline Frochot Laurent Miclo Piotr Orlewski Michel Marraud Jean-Luc Gaillard Manh Thong Cung and Régis Vanderesse

Institution:	(1) LCPM, CNRS-URA 494, ENSIC-INPL, BP 451, F-54001 Nancy Cedex, France;(2) LBSA, Unité associée à l'INRA, Université Henri Poincaré, BP 239, F-54506 Vandoeuvre lès Nancy Cedex, France

Abstract:	The conformation of a benzodiazepine-like decapeptide corresponding tothe YLGYLEQLLR fragment of a casein has been examined in a sodium dodecylsulfate micellar medium using circular dichroism, two-dimensional¹H NMR spectroscopy and restrained molecular dynamicssimulation. The decapeptide adopts an amphipathic 3₁₀-helicoidstructure in which theE⁶···R¹⁰ ionic bridgestabilizes the C-terminus.

Keywords:	Benzodiazepines Circular dichroism GABA_Areceptor Micellar medium Molecular dynamics 2D NMR
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