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A seventh complementation group in excision-deficient xeroderma pigmentosum. |
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| Authors: | W Keijzer N G Jaspers P J Abrahams A M Taylor C F Arlett B Zelle H Takebe P D Kinmont D Bootsma |
| Affiliation: | 1. Department of Cell Biology and Genetics, Erasmus University, P.O. Box 1738, Rotterdam, The Netherlands;2. Laboratory for Physiological Chemistry, Sylvius Laboratories, Leiden, The Netherlands;3. Department of Cancer Studies, Medical School, Birmingham B15 9QH, Great Britain;4. Cell and Mutation Unit, University of Sussex, Falmer, Brighton BN1 9QH, Great Britain;5. Medical Biological Laboratory TNO, Rijswik, The Netherlands;6. Radiation Biology Center, Kyoto University, Kyoto 606, Japan;7. Department of Dermatology, The General Hospital, Nottingham NGI GHA, Great Britain |
| Abstract: | Cells from a xeroderma pigmentosum patient XP2BI who has reached 17 years of age with no keratoses or skin tumours constitute a new, 7th complementation group G. These cells exhibit a low residual level of excision repair, 2% of normal after a UV dose of 5 J/m2 and an impairment of post-replication repair characteristic of excision-defective XPs. They are also sensitive to the lethal effects of UV and defective in host-cell reactivation of UV-irradiated SV40 DNA. |
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