Polyelectrolyte complexes of gum kondagogu and chitosan,as diclofenac carriers |
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Authors: | VGM Naidu K Madhusudhana RB Sashidhar S Ramakrishna Roop K Khar Farhan J Ahmed Prakash V Diwan |
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Institution: | 1. Pharmacology Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, Andhra Pradesh, India;2. National Institute of Pharmaceutical and Education Research, Hyderabad, Andhra Pradesh, India;3. Department of Biochemistry, University College of Sciences, Osmania University, Hyderabad 500 007, Andhra Pradesh, India;4. Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard (Deemed) University, Hamdard Nagar, New Delhi, India |
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Abstract: | Polyelectrolyte complexes (PEC) of gum kondagogu (GKG) and chitosan were prepared by mixing polymeric solutions of different concentrations (0.02–0.18% w/v). The complex formed were loaded with diclofenac sodium, and the release of the drug was measured in vitro and in vivo, along with the measurement of particle size, zeta potential, complex formation, flow properties, and loading efficiency. Maximum yield of PEC was observed at gum kondagogu concentrations above 80%. The PEC showed lower release of diclofenac sodium in 0.1 N HCl as compared to phosphate buffer (pH 6.8). Increasing the concentration of gum kondagogu in PEC led to an increase in drug release. However, PEC 1:3 (gum kondagogu: chitosan) with higher concentration of chitosan showed 98% release with in 4.5 h, owing to the fact that chitosan has a higher degree of swelling in acidic medium. PEC 5:1 and 3:1 showed a 5.3- and 5.8-fold increase in relative bioavailability compared to the free drug when administered orally to the rats. |
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