| 肿瘤抑制基因Rb与细胞周期调控研究新进展 |
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| 引用本文： | 范祖森,敖世洲. 肿瘤抑制基因Rb与细胞周期调控研究新进展[J]. 生物化学与生物物理进展, 1999, 26(5): 429-433 |
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| 作者姓名： | 范祖森 敖世洲 |
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| 作者单位： | 中国科学院上海生物化学研究所,分子生物学国家重点实验室,上海,200031 |
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| 摘 要： | Rb与人类多种肿瘤发生关系密切，是一种重要的肿瘤抑制基因.Rb蛋白参与细胞周期调控，与p16、CDK4/6、cyclinD1等形成复杂的反馈调节网络，在G1/S关卡调控中处于中心环节，决定着细胞周期的进程.Rb又是核内信号与胞外信号相互作用的界面，受到胞内外多种因素的调控，使Rb功能与细胞生长、分化状态相适应.
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| 关 键 词： | Rb基因，细胞周期，关卡调控，肿瘤 |
| 收稿时间： | 1998-09-14 |
| 修稿时间： | 1999-03-08 |
Recent Progress in the Correlation Between Tumor Suppressor Gene Rb and Checkpoint Control in Cell Cycle |
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| FAN Zu-Sen and AO Shi-Zhou. Recent Progress in the Correlation Between Tumor Suppressor Gene Rb and Checkpoint Control in Cell Cycle[J]. Progress In Biochemistry and Biophysics, 1999, 26(5): 429-433 |
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| Authors: | FAN Zu-Sen and AO Shi-Zhou |
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| Abstract: | Rb correlates with tumorigenesis closely, and is an important tumor suppressor gene. Rb protein forms a complicated feedback regulation pathway combined with p16, CDK4/6, cyclinD1 to control cell cycle. Rb is a central step in G1/S checkpoint control to determine cell cycle progression. Rb protein acts as an interface of interaction between nuclear and extracellular signals and is controlled by many extracellular factors which control cell growth and differentiation. |
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| Keywords: | Rb gene cell cycle checkpoint control tumor |
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