Pharmacomodulation of a sulfamide 5-HT6 receptor ligand |
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| Authors: | Renault Jacques Bernard Aurelie Brajeul Solenn Verhaeghe Pierre Butt Sabrina Fabis Frederic Dauphin François Uriac Philippe Rault Sylvain |
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| Institution: | UPRES EA 2234- Institut de Chimie de Rennes, Faculté des Sciences Biologiques et Médicales, Université de Rennes 1, 35043 Rennes, France. jacques.renault@univ-rennes1.fr |
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| Abstract: | A series of N-omega-aminoalkyl- or N-omega-amidinoalkyl-2,4,6-triisopropyl benzenesulfonamides has been synthesized and their respective affinity indices on 5-HT6 receptor determined. This evaluation clearly showed that the compounds possessing an arylpiperazine moiety or an amidine function exhibited good affinity for the model. |
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