The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease |
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| Authors: | Péter Bai Carles Cantó |
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| Affiliation: | Department of Medical Chemistry, University of Debrecen, Medical and Health Science Center, Debrecen 4032, Hungary; Cell Biology and Signaling Research Group of the Hungarian Academy of Sciences, Debrecen 4032 Hungary. |
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| Abstract: | ![]()
While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications. |
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