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The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease
Authors:Péter Bai  Carles Cantó
Affiliation:Department of Medical Chemistry, University of Debrecen, Medical and Health Science Center, Debrecen 4032, Hungary; Cell Biology and Signaling Research Group of the Hungarian Academy of Sciences, Debrecen 4032 Hungary.
Abstract:
While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.
Keywords:
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