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Cyclooxygenase and 5-lipoxygenase inhibitory activity of 2,6 di-t-butylphenols linked by a sulfur atom to 1,3,4-thiadiazoles and 1,3,4-oxadiazoles |
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| Authors: | James B Kramer Diane H Boschelli David T Connor Catherine R Kostlan Paul J Kuipers John A Kennedy Clifford D Wright Dirk A Bornemeier Richard D Dyer |
| Institution: | a Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company 2800 Plymouth Rd., Ann Arbor, MI 48105 U.S.A. b Department of Immunopathology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company 2800 Plymouth Rd., Ann Arbor, MI 48105 U.S.A. c Department of Biochemistry Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company 2800 Plymouth Rd., Ann Arbor, MI 48105 U.S.A. |
| Abstract: | The preparation of a series of 1,3,4-thiadiazoles and 1,3,4-oxadizoles linked by a thioether to 2,6-di-t-butylphenol and the inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) by these compounds is dicussed. |
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