A single succinic semialdehyde dehydrogenase is involved in 4-hydroxyphenylacetate and 4-aminobutyrate catabolism in Klebsiella pneumoniae M5a1 |
| |
Authors: | Estrella Ferrer Ronald A Cooper |
| |
Institution: | Department of Biochemistry, University of Leicester, Leicester, U.K. |
| |
Abstract: | Abstract Klebsiella pneumoniae M5a1 grows readily on two compounds, 4-hydroxyphenylacetate and 4-aminobutyrate, whose catabolism produces succinic semialdehyde. A single succinic semialdehyde dehydrogenase was detected, native molecular weight 52000, that has NAD as the preferred cofactor and is induced by succinic semialdehyde functions in the oxidation of succinic semialdehyde during growth on both 4-hydroxyphenyl-acetate and 4-aminobutyrate. This contrasts with the situation for Escherichia coli and Pseudomonas putida where two distinct forms of succinic semialdehyde dehydrogenase have been observed. |
| |
Keywords: | Klebsiella pneumoniae Succinic semialdehyde dehydrogenase 4-Hydroxyphenylacetate 4-Aminobutyrate |
|
|