The special location of p-H3 and p-CENP-A on heterochromatin during mitosis in MCF-7 |
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| Authors: | Dengwen Li Ruming Liu Liping Song Hao Zhou Jiatong Chen Xitai Huang |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, NanKai University, Tianjin, 300071, China |
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| Abstract: | CENP-A locates at nucleosome as histone H3-like proteins, and is phosphorylated during mitosis. We investigated the dynamic
distribution of p-CENP-A to explore the details of its function. We found that p-CENP-A was phosphorylated at late prophase,
and the signal of p-CENP-A arranged at equatorial plate along with nucleosomes at metaphase, but moved to midbody at later
phase of mitosis. The phosphorylation modification of CENP-A shares some characters of H3, but has different temporal patterns
during mitosis. Our results suggested that the CENP-A might have similar functions as H3, but with different patterns for
their different binging materials.
Dengwen Li and Ruming Liu had contributed equally to this paper. |
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| Keywords: | Mitosis Ser10 phosphorylated H3 Ser7 phosphorylated CENP-A |
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