Distribution and metabolism of iron in muscles of iron-deficient rats |
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Authors: | Yoshinobu Ohira Jack Hegenauer Paul Saltman V Reggie Edgerton |
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Institution: | (1) Department of Biology, University of California, San Diego, 92093 La Jolla, California;(2) Department of Kinesiology, University of California, Los Angeles, 90024 Los Angeles, California |
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Abstract: | Iron-deficiency anemia leads directly to both reduced hemoglobin levels and work performance in humans and experimental animals.
In an attempt to observe a direct link between work performance and insufficient iron at the cellular level, we produced severe
iron deficiency in female weanling Sprague-Dawley rats following five weeks on a low-iron diet. Deficient rats were compared
with normal animals to observe major changes in hematological parameters, body weight, and growth of certain organs and tissues.
The overall growth of iron-deficient animals was approximately 50% of normal. The ratio of organ weight: body weight increased
in heart, liver, spleen, kidney, brain, and soleus muscle in response to iron deficiency. Further, mitochondria from heart
and red muscle retained their iron more effectively under the stress of iron deficiency than mitochondria from liver and spleen.
Metabolism of iron in normal and depleted tissue was measured using tracer amounts of59Fe administered orally. As expected, there was greater uptake of tracer iron by iron-deficient animals. The major organ of
iron accumulation was the spleen, but significant amounts of isotope were also localized in heart and brain. In all muscle
tissue examined the59Fe preferentially entered the mitochondria. Enhanced mitochondrial uptake of iron prior to any detectable change in the hemoglobin
level in experimental animals may be indicative of nonhemoglobin related biochemical changes and/or decrements in work capacity. |
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Keywords: | Iron distribution and metabolism in rat muscle metabolism of Fe in rat muscle rat muscle Fe distribution and metabolism in iron deficiency in rat muscle Fe distribution and metabolism in anemia effect on hemoglobin levels and work performance hemoglobin effect of Fe deficiency on work performance effect of Fe deficiency on |
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