The Chronological Characteristics of SOD1 Activity and Inflammatory Response in the Hippocampi of STZ-Induced Type 1 Diabetic Rats |
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Authors: | Sun Shin Yi In Koo Hwang Dae Won Kim Jae Hoon Shin Sung Min Nam Jung Hoon Choi Choong Hyun Lee Moo-Ho Won Je Kyung Seong Yeo Sung Yoon |
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Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Biomedical Sciences, Division of Life Sciences, Hallym University, Chuncheon, 200-702, South Korea;(3) Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(4) Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(5) Department of Biomedical Sciences, College of Health Sciences, Marquette University, Milwaukee, WI 53233, USA |
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Abstract: | Because it appears that oxidative stress and inflammation are implicated with disease pathogenesis in the diabetic brain,
many researchers have used streptozotocin (STZ)-induced diabetic animals to study superoxide production and the effects of
superoxide scavengers like Cu,Zn-superoxide dismutase (SOD1). However, many studies have been conducted without considering
temporal changes after STZ injection. Interestingly, though SOD activities were not significantly different among the groups,
SOD1 and 4-hydroxy-2-nonenal (4-HNE) immunoreactivities were significantly enhanced at 3 weeks after an STZ injection (STZ3w)
versus only marginal levels in sham controls, whereas microglial activity was remarkably reduced in injected rats at this
time. However, SOD1 immunoreactivity and microglial activities were only at the sham level at STZ4w. The present study provides
important information concerning cell damage by ROS generated by STZ. Microglial response was found to be inactivated at STZ3w
and neuronal cells (NeuN) showed a non-significant tendency to be reduced in number at STZ4w except in the dentate gyrus.
We speculated that the above oxidative stress-related events should be accomplished at STZ3w in the brains of STZ-induced
diabetes animal models. Therefore, the aim of the present study was to investigate chronological changes in SOD1 immunoreactivity
associated with lipid peroxidation and inflammatory responses in the hippocampi of STZ-induced type I diabetic rats. |
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