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Heterocyclic ketones as inhibitors of histone deacetylase |
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| Authors: | Vasudevan Anil Ji Zhiqin Frey Robin R Wada Carol K Steinman Douglas Heyman H Robin Guo Yan Curtin Michael L Guo Jun Li Junling Pease Lori Glaser Keith B Marcotte Patrick A Bouska Jennifer J Davidsen Steven K Michaelides Michael R |
| Institution: | Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com |
| Abstract: | Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition. |
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