Triggering antiviral response by RIG-I-related RNA helicases |
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| Authors: | Fujita Takashi Onoguchi Kazuhide Onomoto Koji Hirai Reiko Yoneyama Mitsutoshi |
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| Institution: | Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. tfujita@virus.kyoto-u.ac.jp |
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| Abstract: | TLRs detect several classes of virus-associated molecules, such as ssRNA, CpG-DNA and dsRNA, and transduce signals leading to the production of IFN. Recently discovered cytoplasmic RNA helicases, RIG-I and MDA5, selectively sense viral RNA species. Gene disruption studies revealed the critical but non-redundant function of RIG-I and MDA5 in host antiviral responses. |
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