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MPTP as a Mitochondrial Neurotoxic Model of Parkinson's Disease |
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| Authors: | Serge Przedborski Kim Tieu Celine Perier Miquel Vila |
| Affiliation: | Department of Neurology, Columbia University, New York, New York 10032, USA. sp30@columbia.edu |
| Abstract: | 1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent neurotoxin extensively used to model Parkinson's disease (PD). A cascade of deleterous events, in which mitochondria play a pivotal role, drives MPTP neurotoxicity. How mitochondria are affected by MPTP and how their defect contributes to the demise of dopaminergic neurons in this model of PD are discussed in this review. |
| Keywords: | MPTP Parkinson's disease neurodegeneration mitochondria oxidative stress ATP depletion programmed cell death |
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