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Bayesian DNA copy number analysis |
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| Authors: | Paola MV Rancoita Marcus Hutter Francesco Bertoni Ivo Kwee |
| Institution: | 1. Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA), Galleria 2, 6928, Manno-Lugano, Switzerland 2. Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland (IOSI), via Vela 6, 6500, Bellinzona, Switzerland 3. Dipartimento di Matematica, Università degli Studi di Milano, via Saldini 50, 20137, Milano, Italy 4. RSISE, ANU and SML, NICTA, Canberra, ACT, 0200, Australia |
| Abstract: | BackgroundSome diseases, like tumors, can be related to chromosomal aberrations, leading to changes of DNA copy number. The copy number of an aberrant genome can be represented as a piecewise constant function, since it can exhibit regions of deletions or gains. Instead, in a healthy cell the copy number is two because we inherit one copy of each chromosome from each our parents. |
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