进展期胃癌p53表达与微血管密度及生物学行为的关系

目的探讨进展期胃癌生长过程中p53基因表达与微血管密度和生物学行为之间的关系。方法搜集有随访资料的胃癌标本107例,用免疫组化对突变型p53和CD34作了标记,用原位杂交对野生型p53作了检测。结果突变型p53在肿瘤不同侵犯深度、不同生长方式、不同淋巴结转移状态以及预后方面,存在显著差异(P<0.05),突变型p53与微血管密度显著相关(P<0.05),而野生型p53则与突变型p53相反。结论突变型和野生型p53在肿瘤生长过程中的表达不同,说明p53的不同功能状态在肿瘤的发展过程中发挥重要作用。

RELATIONSHIP AMONG P53 EXPRESSION, MICROVESSEL DENSITY AND THE BIOLOGIC BEHAVIOR IN PROGRESSIVE GASTRIC CARCINOMA

Objective To explore the p53 gene expression and microvessel density as well as the biologic behavior in the development of gastric carcinoma.Methods 107 cases with followed-up data were collected and analyzed.Immunohistochemistry and in situ hybridization were performed to inspect p53 and CD34 proteins and p53 mRNA.Results Mutant type p53 expression was significant different in different conditions of invasion depth,growth pattern,lymph node metastasis,and prognosis(P<0.05),showed had a close relationship with microvessel density(P<0.05),whereas wild type p53 expression had opposite characteristics.Conclusion The expressions of mutant type and wild type p53 are different in the development of gastric carcinoma,which means that the different function states of p53 play an important role in the growth of gastric carcinoma.