Effect of lactoferrin on the growth of a human colon adenocarcinoma cell line-comparison with transferrin |
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Authors: | M Amouric J Marvaldi J Pichon F Bellot C Figarella |
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Institution: | (1) Inserm U 31, 46 Boulevard de la Gaye, 13258 Marseille Cedex, France;(2) Faculté des Sciences, Institute de Chimie Biologique, Place Victor Hugo, 13331 Marseille, France |
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Abstract: | Summary Lactoferrin was examined for its effect on the growth of a human colon adenocarcinoma cell line (HT 29) in culture and its
action was compared to that produced by transferrin and two different iron solutions (ferrous sulfate and ferric chloride).
When transferrin was replaced by either iron solutions the cell grew in proportion to the quantity added and the maximal effect
obtained was identical to that produced by transferrin alone. When transferrin was replaced by lactoferrin the cells were
unable to proliferate for a long time. However, in the presence of low-concentration iron solutions, lactoferrin stimulated
the cell growth, and the effect was more pronounced with the ferric chloride solution.
This work was supported by Grants Inserum 817014 and LA CNRS 202. |
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Keywords: | lactoferrin cell growth serum-free medium transferrin |
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