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Chromosome aberrations induced by protons up to 31 MeV in cultured human cells
Authors:D. Bettega  S. Dubini  A. M. Fuhrman Conti  T. Pelucchi  L. Tallone Lombardi
Affiliation:(1) Gruppo di Fisica Medica - Istituto di Fisica, Università degli Studi di Milano and Istituto di Fisica Nucleare - Sezione di Milano, Via Celoria 16, I-20133 Milano, Italy;(2) Istituto di Biologia Generale, Facoltà di Medicina, Università degli Studi di Milano, Via Viotti 3, I-20133 Milano, Italy
Abstract:Summary Chromosome aberrations were induced in cultured human cells by proton beams of 31, 12, and 8 MeV. The frequencies of isocromatid breaks and dicentrics have been analysed as a function of proton energy and dose. Both effects are largely dependent on proton energy; isochromatid breaks increase linearly with the dose, whereas dicentrics show a definite parabolic behaviour. The experimental data were fitted to the analytic formY = KD n andY = agrD +betaD 2 and the best fitted values of the parameters are reported and discussed. The values of RBE for the isochromatid breaks are in the ratio 1.7: 1.3: 1 for 8, 12, and 31 MeV respectively.In the case of the dicentrics the RBE values are dose-dependent function of the typeCD –n . The three distributions of dicentrics among the cells do not fit a Poisson distribution.Supported by a grant of CNR no 790067996 of the Finalized Project ldquoTumour Growth Control201D; Consiglio Nazionale delle Ricerche, Italy
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