Steroidal saponins from Tribulus terrestris |
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| Authors: | Lan Su Gang Chen Sheng-Guang Feng Wei Wang Zhi-Feng Li Huan Chen Ying-Xue Liu Yue-Hu Pei |
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| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, PR China;2. School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang 110016, PR China;1. Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion, Suwon 443-766, Republic of Korea;2. College of Pharmacy, Dankook University, Cheonan 330-714, Republic of Korea;1. Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany;2. University of Nizwa, Chair of Oman''s Medicinal Plants and Marine Natural Products, PO Box 33, Birkat Al-Mauz, Nizwa, Oman;1. Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt;2. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA;3. Botany Department, Ecology, Faculty of Science, Mansoura University, Mansoura 35516, Egypt |
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| Abstract: | Five new steroidal saponins were isolated from the fruits of Tribulus terrestris. Their structures were fully established by spectroscopic and chemical analysis as (23S,25S)-5α-spirostane-24-one-3β,23-diol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (1), (24S,25S)-5α-spirostane-3β,24-diol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (2), 26-O-β-d-glucopyranosyl-(25R)-5α-furostan-2α,3β,22α,26-tetraol-3-O-{β-d-glucopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 4)-β-d-galactopyranoside} (3), 26-O-β-d-glucopyranosyl-(25R)-5α-furostan-20(22)-en-2α,3β,26-triol-3-O-{β-d-glucopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 4)-β-d-galactopyranoside} (4), and 26-O-β-d-glucopyranosyl-(25S)-5α-furostan-12-one-22-methoxy-3β,26-diol-3-O-{α-l-rhamnopyranosyl-(1 → 2)-O-β-d-glucopyranosyl-(1 → 4)]-β-d-galactopyranoside} (5). The isolated compounds were evaluated for cytostatic activity against HL-60 cells. |
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